Beilstein J. Nanotechnol.2016,7, 1871–1877, doi:10.3762/bjnano.7.179
adherent cells as an indication of their health status. However, the moist, warm, and corrosive biological environment requires reliable packaging of the sensor chip. In this work, a second generation of lowtemperatureco-firedceramic (LTCC) technology was combined with flip-chip bonding to provide a
medium above the capacitors. Moreover, the manufacturing of microfluidic channels in the LTCC package was demonstrated.
Keywords: capacitance sensing; cell viability; lab-on-a-chip; lowtemperatureco-firedceramic (LTCC); Introduction
Biosafety regulations require ethical, simple, rapid, and cost
% humidity, and a salt-containing medium for growth).
Lowtemperatureco-firedceramic (LTCC) technology in combination with flip-chip bonding is one method of producing durable, biocompatible packaging for LoCMOS devices. The advantage of the LTCC technology is the possibility of fast and simple 3D
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Figure 1:
(a) Layout of the dummy chip mimicking the size of the sensor chip and the contact pad positions an...